Lyosensing is an in-line process analyser based on the application of a quadrupole mass spectrometer system, a non-invasive technique capable of performing quantitative real-time measurements during freeze-drying processes.
Embedded into a lyophiliser, the use of the analyser in Telstar freeze dryers enables detecting and monitoring the presence, as well as the behaviour of several agents that could be present during maintenance operations, performance tests or during the freeze-drying cycle. As a聽process analytical tool (PAT), Lyosensing has been designed by Telstar to monitor potential silicon oil contamination, primary and secondary drying endpoints and perform in-line vacuum leak detection in the field of lyophilisation processes.
While the majority of gas found within the freeze-dryer comes from the sublimation water, other gases are also present from the controlled leak, real or virtual leakages, as well as backstreaming from the vacuum pumps. Used as a contaminant detection tool, Lyosensing allows a safe detection of traces of silicone from the thermal fluid through the shelves circuit.
It is probably one of the principal concerns for freeze dryer users. Trace levels of contaminants present in large systems are often left undetected, which requires a safe preventive control system to avoid loss of a large amount of potentially contaminated product, preserving the integrity of the product, in addition to guaranteeing quality assurance.
The versatility of the equipment allows the user to choose the placement on the freeze-dryer, either on the condenser, on the chamber, or between both locations, depending on the type of process being managed. The in-line process analyser integrated by Telstar allows freeze-drying process cycle monitoring by providing accurate data of the water concentration during primary and secondary drying.
The in-line process Lyosensing, will be exhibiting within the PAT Corner area set up at the Telstar booth at Achema (in Frankfurt from 11 June to 15 June). The company will be displaying the leading-edge innovative developments in the process analytical technology field for pharmaceutical freeze drying systems and aseptic manufacturing processes.
If you have any questions, please make an enquiry using the form on this page, or visit Telstar at Achema in Booth C49, Hall 3.1.