Telstar has announced a new vacuum nucleation induction method in the freeze-drying process that is suitable for a wide range of freeze-dryers without modifying its main elements or adding gases or external substances.
After years of research, Telstar鈥檚 innovation department has unveiled the solution for effectively inducing the start of nucleation in the freeze-drying process, which enables the pharmaceutical industry to run the freeze-drying process of product batches more efficiently, quickly, productively and uniformly by using prescriptions adapted to the specifications of each product.
Called Telstar Lyonuc, the new method will be presented and demonstrated at CPhI, which takes place in Madrid from 9 October to 11 October.
The vacuum-induced nucleation system produces a change in the solid structure of the solution and manages to homogenise the moment when the freezing starts so that all the vials nucleate at the same time in a few seconds, instead of taking 30-45 minutes, which is how long the spontaneous nucleation process can last.
Based on controlling the temperature and pressure and inducing the start of the freezing phase, this method also ensures the uniformity and homogenisation of the vials in all the batches, respecting the product鈥檚 physiochemical properties.
The new vacuum nucleation induction method can be adapted to any type, model or brand of freeze-dryer, as unlike other methods being studied on the market where it is necessary to add gases external to the process or use decompression processes requiring special equipment, this new method only requires measuring and controlling the temperature, vacuum and time parameters and it uses the actual tools of a freeze-drying prescription.
In addition, the new method is particularly indicated for long duration freeze-drying cycles, where the benefit of reducing the drying time is much greater.
As well as improving the theoretical vacuum nucleation induction process developed by Kramer and Liu at the beginning of this century, the research developed by Telstar has delved into the aesthetic behaviour of the freeze-dried solution which is usually altered during the vacuum nucleation induction process.