Agomab’s lead candidate is being investigated as a treatment for patients with fibrostenosing Crohn鈥檚 disease (FSCD). Credit: Hananeko_Studio via Shutterstock.

Agomab Therapeutics has secured $89m in Series D funding to support clinical trials of its fibrotic disease treatments, with some help from .

Belgium-based Agomab announced that Sanofi and Invus have joined as new investors in its latest funding round, following on from a $100m Series C round in October 2023, and a $114m Series B where led an extension round.

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The funds will be used to advance the development of Agomab鈥檚 lead candidate AGMB-129, a treatment for patients with fibrostenosing Crohn鈥檚 disease (FSCD). The oral small molecule inhibitor of ALK5 (TGF尾1R) is currently being investigated in the Phase IIa STENOVA trial (NCT05843578). The company expects to share interim results from the 90-patient trial in early 2025.

Positive data from the (NCT04933565) of AGMB-129 was reported in February 2023, where the candidate demonstrated high local exposure in the ileum, with no drug-related safety signals or dose-limiting toxicities. Patients with FSCD have strictures in the intestines caused by inflammation and scarring, for which there is no cure.

The company also has an inhaled treatment for idiopathic pulmonary fibrosis (IPF), named AGMB-447, and a liver cirrhosis candidate AGMB-101. AGMB-447 is being investigated in a (NCT06181370) and Agomab plans to start clinical development of AGMB-101, which is 鈥渋n the final stages of IND-enabling studies鈥�. 

Sanofi continues to assert itself in the immunology space, signing deals with parties such as Recludix, Teva Pharmaceutical and . The company expanded its immunology pipeline further in June 2024, entering a $700m strategic partnership with Belharra Therapeutics to spur the development of small molecule therapies for immunological diseases.

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Sanofi and Regeneron鈥檚 immune-targeting biologic Dupixent (dupilumab) has been picking up label expansions since its 2017 US Food and Drug Administration (FDA) approval for atopic dermatitis. The drug earned $11.6bn last year, as per Regeneron鈥檚 financials, and is set to generate $23.6bn in 2030, according to GlobalData consensus forecasts.

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In the announcement accompanying the funding, Agomab鈥檚 CEO Tim Knotnerus said: 鈥淲e are thrilled to have Sanofi and Invus joining our investor syndicate. Their investment as well as the continued support from our existing shareholders is another validation of the trailblazing work our team is conducting in the fields of fibrostenosing Crohn鈥檚 disease and idiopathic pulmonary fibrosis.鈥�