England鈥檚 National Institute for Health and Care Excellence () has recommended 鈥檚 Ebglyss (lebrikizumab) for patients with moderate to severe atopic dermatitis, giving NHS patients another biological therapy option.
In line with NICE guidelines, the NHS will now have 90 days to make the treatment available to patients.
Patients over 12 years of age who have not responded to or are not able to take systemic immunosuppressants will be eligible for the therapy, as per a 10 July press release.
Monoclonal antibody Ebgylss will join / Regeneron鈥檚 Dupixent (dupilumab) and 鈥檚 Adbry (tralokinumab) as interleukin-targeting options for treating the skin condition. The Janus kinase (JAK) inhibitors Cibinqo (abrocitinib), Olumiant (baricitinib), and Rinvoq (upadacitinib) developed by , Eli Lilly, and , respectively, are also recommended by NICE.
Atopic dermatitis, also known as atopic eczema, is an inflammatory skin condition characterised by intense itching. It has an estimated prevalence of up to 4.4% among adults in the EU. In the UK alone, around have moderate to severe atopic dermatitis.
Ebglyss, which was approved in Europe in October 2023, and then two months later in the UK, works by inhibiting interleukin-13 (IL-13) signalling. IL-13 pathways play an important role in inflammation, driving the type-2 inflammatory loop in the skin. Adbry similarly targets IL-13 while Dupixent inhibits IL-13 and IL-4.
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By GlobalDataThe National Eczema Society鈥檚 chief executive Andrew Proctor said: 鈥淚t鈥檚 important we have a range of treatment options, so patients have the chance to access a treatment that works well for them.鈥�
Almirall licensed the rights to develop and commercialise Ebglyss in dermatology indications, including atopic dermatitis, in Europe from Dermira in 2019. Dermira was then acquired by Eli Lilly, the latter retaining drug rights in the US and the rest of the world.
Ebglyss is forecast to reach blockbuster status by 2026, according to GlobalData鈥檚 Pharma Intelligence Centre. By 2030, the drug is predicted to generate nearly $3.4bn in global sales.
GlobalData is the parent company of Pharmaceutical Technology.
Amid Sanofi and Regeneron鈥檚 Dupixent dominance, (J&J) made a play for the atopic dermatitis space earlier this year when it spent $1.25bn to acquire Numab Therapeutics鈥� antibody NM26 in May.
