Low magnification micrograph of the distal right coronary artery with complex atherosclerosis and luminal narrowing. Credit: Nephron / commons.wikipedia.org.

Kyttaro has signed an to obtain an exclusive global licence for Company鈥檚 anti-angiopoietin-like (ANGPTL) 3/8 monoclonal antibody programme to treat atherosclerotic cardiovascular disease (ASCVD).

The antibody will also be developed to treat various other conditions, including ASCVD-associated dyslipidemias: hypertriglyceridemia and .

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Two genetically established targets for ASCVD, ANGPTL3 and ANGPTL8 form the ANGPTL3/8 complex, an endogenous lipoprotein lipase (LPL) inhibitor. 

The Kyttaro-acquired anti-ANGPTL3/8 antibodies have shown an increased affinity for the target and robust potential for the treatment of individuals who are at high-risk for ASCVD based on their ability to boost LPL activity and reduce triglycerides. 

People with loss-of-function mutations in ANGPTL3 and ANGPTL8 proteins are observed to be healthy and showed reduced triglyceride and LDL levels.

Furthermore, such mutations present substantially lowered cardiovascular disease occurrence.

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Data from epidemiological studies demonstrated that increased triglycerides are a key risk factor for cardiovascular events and severe hypertriglyceridemia is linked to a rare and possibly fatal condition called acute pancreatitis.

The companies have not disclosed the financial details of the agreement.

Kyttaro founder and CEO Douglas Eby said: 鈥淗eart disease stubbornly ranks as the world鈥檚 leading cause of death and the Kyttaro team is resolute in its goal to change the paradigm in ASCVD. 

鈥淭he anti-ANGPTL3/8 antibody programme positions our company brilliantly in an extremely large unmet medical zone, with the clear opportunity to make a significant impact in the lives of millions of patients suffering from disease.鈥�

The latest development comes after Lilly signed an agreement to licence radiolabelled forms of its olaratumab antibody to Telix Pharmaceuticals for cancer treatment and diagnosis.