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Clover Biopharmaceuticals has generated a trimeric Spike-protein (S-Trimer) subunit vaccine candidate against the new 2019-nCoV coronavirus.
The company used a mammalian cell expression system to produce the vaccine candidate.
Subsequently, researchers at Clover could identify antigen-specific antibody using S-Trimer in sera of various fully recovered coronavirus-infected patients.
The company is the first to unveil a vaccine candidate that can be detected by antibodies generated by previously-infected patients. This indicates that the vaccine candidate may trigger a protective immune response.
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By GlobalDataClover carried out development activities in alliance with China-based Chengdu Hi-Tech Park and Chengdu Clinical Center for Public Health teams.
Clover Biopharmaceuticals co-founder, chairman and president Dr Peng Liang said: 鈥淭he implication of this discovery is that it not only has validated the correct conformation of our S-Trimer subunit vaccine candidate but also further supports that the new 2019-nCov virus is indeed the culprit for the current epidemic since all previous diagnosis for the viral infections have been based on nucleic acid detection.
鈥淭his important finding forms a solid foundation for the continued rapid development of S-Trimer vaccine through pilot production, preclinical efficacy and safety studies, followed by human clinical trials and subsequent large-scale production.鈥�
2019-nCoV is an RNA virus that consists of a trimeric spike (S) protein on its viral envelope. The trimeric S protein enables attachment to host cell surface receptor ACE2 and viral entry.
The company began designing viral S-protein construct聽last month, completing gene synthesis, following the publication of 2019-nCoV genomic DNA sequence.
Clover Trimer-Tag technology produced an S-Trimer subunit vaccine through a rapid mammalian cell-culture based expression system.
The company鈥檚 commercial-scale biomanufacturing capabilities in China should facilitate the production of high quantities of a new coronavirus vaccine.
