has signed a collaboration and licensing agreement with for the research and development of chimeric antigen receptor (CAR)-T cell therapeutics.
Even though allogeneic, 鈥榦ff-the-shelf鈥� CAR-T cell therapies demonstrated early promise in some cancer patients and there exists a need for overcoming the allogeneic CAR-T cell rejection by the host immune system.
Using Caribou鈥檚 CRISPR genome editing platform to engineer CAR-T cells to withstand host immune attack would aid in developing the next-generation of 鈥榦ff-the-shelf鈥� cellular therapies to benefit a wider population of patients.
Under the agreement, AbbVie will carry out research and development of two new CAR-T cell therapies directed to targets specified by the company, by leveraging Caribou’s next-generation Cas12a CRISPR hybrid RNA-DNA (chRDNA) genome editing and cell therapy technologies.
AbbVie will have exclusive rights to the Caribou’s genome editing and cell therapy technologies for the selected targets.
For the collaboration programmes, Caribou will carry out specific pre-clinical research, development and manufacturing activities and AbbVie will reimburse Caribou for all activities under the partnership.
How well do you really know your competitors?
Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.
Thank you!
Your download email will arrive shortly
Not ready to buy yet? Download a free sample
We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form
By GlobalDataAs per the deal, AbbVie is in charge of all clinical development, commercialisation and manufacturing. It also holds an option to pay a fee to expand the partnership to include up to two more CAR-T cell therapies.
In this regard, Caribou will get a $40m upfront cash payment and equity investment, as well as up to $300m as future development, regulatory and launch milestones.
It may also receive additional payments for commercial milestones and global tiered royalties.
Caribou Biosciences president and CEO Rachel Haurwitz said: 鈥淭his collaboration validates Caribou鈥檚 differentiated next-generation CRISPR genome editing technologies that provide best-in-class efficiency and specificity.
鈥淕enome-edited CAR-T cell therapies hold tremendous potential for patients, and this partnership accelerates our ability to address significant unmet medical need.”
Meanwhile, the US Food and Drug Administration (FDA) has approved AbbVie company Allergan鈥檚 BOTOX for treating detrusor (bladder muscle) overactivity linked to a neurologic condition in paediatric patients aged five years and above.
The approval derives from data of a Phase III study, which showed that intradetrusor administration of BOTOX 200 Units reduced daytime urinary incontinence episodes and decreased maximum bladder pressure and increased bladder capacity at week six.
Last September, AbbVie entered a global collaboration agreement with I-Mab to develop and commercialise lemzoparlimab (TJC4), an immuno-oncology therapy.
Cell & Gene Therapy Coverage on Pharmaceutical Technology supported by Cytiva.
Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.
