Selpercatinib is under clinical development by and currently in Phase II for Sarcomas. According to GlobalData, Phase II drugs for Sarcomas have a 27% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Selpercatinib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Selpercatinib overview
Selpercatinib (Retevmo, Retsevmo) is a potent antineoplastic agent. It is formulated as hard gelatin capsules for the oral route of administration. It is indicated in the treatment of adult patients with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) following prior treatment with immunotherapy and/or platinum-based chemotherapy, adult and pediatric patients 12 years of age and older with advanced or metastatic RET-mutant medullary thyroid cancer (MTC) who require systemic therapy following prior treatment with cabozantinib and/or vandetanib and with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and who are radioactive iodine-refractory (if radioactive iodine is appropriate) and who require systemic therapy following prior treatment with sorafenib and/or lenvatinib.
Selpercatinib (LOXO-292) is under development for the treatment of Medullary thyroid cancer, non-small cell lung cancer, anaplastic thyroid cancer, follicular thyroid cancer, papillary thyroid cancer, solid tumors including primary central nervous system tumors, pancreatic cancer, breast cancer, ovarian, small intestine cancer, Carcinoid tumor , salivary gland tumor and lung cancer. The drug candidate is administered through oral route. The drug candidate acts by targeting RET receptor tyrosine kinase.
Loxo Oncology overview
a biopharmaceutical company that carries out the development of targeted small molecule therapeutics for the treatment of cancer. The company’s pipeline products include FGFR3 SELECTIVE, PI3Ka INIBITOR, 225Ac-PSMA-62 PNT2001, 225Ac-PSMA-62 PNT2001, NECTIN-4 ADC 1 are for the treatment of cancer; OLOMORASIB: KRAS G12C treats mutant non small cell lung cancer (NSCLC); ABEMACICLIB targets metastatic breast cancer (MBC) sequencing; SELPERCATINIB treats adjuvant RET+ non small cell lung cancer (NSCLC); IMLUNESTRANT for ER+ HER2 metastatic breast cancer (mBC) and adjuvant breast cancer; PIRTOBRUTINIB for relapsed/refractory chronic lymphocytic leukemia (CLL) combination, 1L chronic lymphocytic leukemia (CLL) monotherapy. is headquartered in Stamford, Connecticut, the US.
For a complete picture of Selpercatinib’s drug-specific PTSR and LoA scores,
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