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API peptides and protein-based drugs are promising therapeutics for the treatment of a variety of metabolic and oncological disorders. More than 100 approved peptide-based therapeutics are currently available in the market, while more than 600 peptide-based pharmacological leads are being investigated worldwide, across various phases of development. Biologic API manufacturing companies are, therefore, at the forefront of drug development in the pharmaceutical industry.

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Peptide API products have become popular due to their proven pharmacological value and favourable safety profiles. The increasing demand for API peptide products is in turn increasing the demand for peptide API manufacturers who also offer contract manufacturing services.

Discover the top peptide API manufacturers in contract manufacturing

Pharmaceutical Technology has listed the leading contract manufacturers of API biologics (protein and peptide) based on its intel, insights, and decades-long experience in . The list includes companies that provide various products and services including, but not limited to:

  • Manufacturing of reagents for peptide synthesis
  • Large-scale manufacturing of peptides
  • Manufacturing of biologically active peptides and complex organic molecules
  • Production of therapeutic proteins, such as soluble proteins and lipoproteins
  • Process qualification
  • Stability testing
  • Product purification
  • Downstream processing
  • GMP synthesis
  • Synthesis and production of custom peptides, and
  • Tech transfer support for a wide range of GMP API clinical peptide projects

Protein & Peptide Biologic API Manufacturing Companies

The information contained within the download document is intended for API peptide and API protein manufacturers, pharmaceutical executives, peptide synthesis chemists, purification associates, and any other individual involved in the manufacturing of API proteins and peptides.

The document contains detailed information on the suppliers and their product offerings, alongside contact details to aid your hiring decision.

Related Buyer’s Guides which cover an extensive range of pharmaceutical service providers, equipment manufacturers and technology, can also be found here.

Contract manufacturing opportunities in API peptides and proteins

Advancements in drug design have led to the development of new drug molecules in the form of API peptides and proteins. Selective delivery of these molecules at well-defined dosing regimens and preserving their structural integrity has, however, remained challenging. New techniques are being applied to meet the challenges associated with the formulation and delivery of API peptides and proteins.

Contract peptide API manufacturers can benefit by investing in new technologies and capabilities to handle the production of complex peptide and protein molecules. Contract manufacturers are also exploring technologies that support the large-scale manufacturing of proteins and peptides such as lyophilisation, spray drying and microbial expression.

For full details (including contact details) on the leading companies within this space, download the free Buyer’s Guide below:

Frequently asked questions

  • What is an API biologic and how is it used in pharmaceuticals?

    An API (Active Pharmaceutical Ingredient) biologic refers to a protein or peptide-based substance used in drugs to treat various conditions, including metabolic and oncological disorders. These biologics are crucial because they offer targeted treatment, leveraging complex biological molecules to combat diseases. Manufacturers provide custom production of these API biologics, ensuring that the necessary quality and stability measures are met.

  • Why are peptide-based drugs gaining popularity?

    Peptide-based drugs are gaining traction due to their proven pharmacological value and favourable safety profiles. These therapeutics are effective in targeting specific disease mechanisms with minimal side effects. As a result, they are being increasingly explored in areas like oncology and metabolic disorders. Their precision and safety make them an attractive choice for pharmaceutical development.

  • How do contract manufacturers support API biologics production?

    Contract manufacturers play a vital role in API biologics production by offering specialised services like large-scale peptide synthesis, stability testing, and process qualification. They ensure that manufacturing processes adhere to Good Manufacturing Practices (GMP), which is critical for maintaining the quality and efficacy of peptide and protein-based APIs. These manufacturers also invest in new technologies for improved production and delivery systems.

  • What challenges are faced in the production of API peptides?

    The primary challenges in API peptide production include maintaining the structural integrity of the molecules and ensuring precise dosing. These biologics are delicate and can degrade easily, making it difficult to formulate and deliver them effectively. Manufacturers are tackling these issues through advanced techniques like lyophilisation, microbial expression, and spray drying to preserve peptide stability during production.

  • What are the benefits of using contract manufacturers for peptide synthesis?

    Contract manufacturers offer significant benefits for companies involved in peptide synthesis, including access to advanced technologies, scalability for large-scale production, and expertise in GMP-compliant processes. By outsourcing, pharmaceutical companies can focus on drug development while ensuring that the complex synthesis and production processes are handled efficiently, ultimately reducing time-to-market.