SL-172154 is under clinical development by and currently in Phase I for Myelodysplastic Syndrome. According to GlobalData, Phase I drugs for Myelodysplastic Syndrome have a 76% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how SL-172154’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
SL-172154 overview
SL-172154 is under development for the treatment of advanced or metastatic ovarian cancer, epithelial ovarian cancer, primary peritoneal cancer, fallopian tube cancer, acute myeloid leukemia (AML) and higher-risk myelodysplastic syndromes (HR-MDS). The drug candidates are based on Agonist Redirected Checkpoints (ARC) technology. The drug candidate is a two-sided human fusion protein incorporating the ECDs of SIRPα and CD40L, adjoined by a central Fc domain termed as SIRPα-Fc-CD40L. It is administered through intravenous route.
It was under development for the treatment of recurrent head and neck cancer squamous cell carcinoma, cutaneous squamous cell carcinoma, skin cancer, colon cancer and hematological malignancies.
Shattuck Labs overview
is a biotechnology company that develops novel therapeutics for the treatment of cancer and autoimmune diseases. The company’s lead product candidate is SL-172154, a compound currently in global clinical trials for the treatment of cancer. The company utilizes the ARC platform. products are primarily used in the medical field, specifically in the treatment of cancer and autoimmune diseases. is headquartered in Durham, North Carolina, US.
For a complete picture of SL-172154’s drug-specific PTSR and LoA scores,
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