UCART-123 is under clinical development by and currently in Phase I for Relapsed Acute Myeloid Leukemia. According to GlobalData, Phase I drugs for Relapsed Acute Myeloid Leukemia have a 70% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how UCART-123’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
UCART-123 overview
UCART-123 is under development for the treatment of acute myeloid leukemia, Hodgkin lymphoma. It is administered through intravenous route. The therapeutic candidate acts by targeting CD123 antigen. It is developed based on CAR-T platform technology. It was also under development for the treatment of chronic myelocytic leukemia (CML), hairy cell leukemia (HCL), myelodysplastic syndrome (MDS), blastic plasmacytoid dendritic cell neoplasm and pediatric leukemias.
Cellectis overview
, operates as a clinical-stage biopharmaceutical company. The company’s pipeline products include UCART22 is for the treatment of acute lymphoblastic leukemia; UCART123 targets acute myeloid leukemia; UCART20x22 treats non hodgkin lymphoma; cemacabtagene ansegedleucel for large b cell lymphoma, chronic lymphocytic leukemia; ALLO-715, ALLO-605 are for the treatment of multiple myeloma; ALLO-316 for renal cell carcinoma. It works in partnership with Allogene Therapeutics, Servier, Iovance Biotherapeutics, Inc, Cytovia Therapeutics, Inc. It operates in New York and Paris. is headquartered in Paris, France.
For a complete picture of UCART-123’s drug-specific PTSR and LoA scores,
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